Our aim has been to address a series of issues including the new requirements and forms of industrial and technological development associated with the Knowledge Era and the role, objectives and tools of industrial and technology policies in this new international context. Particular emphasis is given to the challenges posed to developing countries and regions. Besides elaborating a conceptual and methodological framework, we have conducted empirical research investigating the recent experience of productive arrangements and innovation systems operating in different sectors and regions in Brazil and other Mercosur countries. These have included the analysis of: